Structure of PDB 4rtm Chain A

Receptor sequence
>4rtmA (length=245) Species: 1110693 (Escherichia coli str. K-12 substr. MDS42) [Search protein sequence]
KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYIL
ADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQ
DPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFA
EKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSNSFTLEQQAHLAEI
AEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKKVDELLALYKP
3D structure
PDB4rtm Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repression.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R95 R124 N126 L127 N132 P134 R93 R122 N124 L125 N130 P132
BS02 SAM A W10 G12 P34 F35 V36 G37 A38 D54 I55 S164 Y165 D181 F201 W8 G10 P32 F33 V34 G35 A36 D52 I53 S162 Y163 D179 F189
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
GO:0043565 sequence-specific DNA binding
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006298 mismatch repair
GO:0009307 DNA restriction-modification system
GO:0009411 response to UV
GO:0032259 methylation
GO:1902328 bacterial-type DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rtm, PDBe:4rtm, PDBj:4rtm
PDBsum4rtm
PubMed25845600
UniProtP0AEE8|DMA_ECOLI DNA adenine methylase (Gene Name=dam)

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