Structure of PDB 4rt7 Chain A

Receptor sequence
>4rt7A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
YDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISGVSIQVAVKMLKDSS
EREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYL
RSKRNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK
ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGI
LLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCW
AFDSRKRPSFPNLTSFLGCQLADA
3D structure
PDB4rt7 Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D811 R815 N816 D829
Catalytic site (residue number reindexed from 1) D135 R139 N140 D153
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P30 A L616 E661 F691 Y693 C694 G697 L818 C828 D829 F830 L18 E58 F88 Y90 C91 G94 L142 C152 D153 F154 BindingDB: Kd=1.6nM,IC50=69nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4rt7, PDBe:4rt7, PDBj:4rt7
PDBsum4rt7
PubMed25847190
UniProtP36888|FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 (Gene Name=FLT3)

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