Structure of PDB 4rqi Chain A

Receptor sequence
>4rqiA (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]
AGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLG
KEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTE
FTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLR
NDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKK
ALK
3D structure
PDB4rqi A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
ChainA
Resolution2.4405 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R80 Q84 S98 L101 R102 Q105 R109 C118 S119 F120 D121 M122 S131 R38 Q42 S56 L59 R60 Q63 R67 C76 S77 F78 D79 M80 S89
BS02 peptide A R72 G74 D75 R30 G32 D33
Gene Ontology
Molecular Function
GO:0042162 telomeric DNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0031848 protection from non-homologous end joining at telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rqi, PDBe:4rqi, PDBj:4rqi
PDBsum4rqi
PubMed26748096
UniProtQ15554|TERF2_HUMAN Telomeric repeat-binding factor 2 (Gene Name=TERF2)

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