Structure of PDB 4rpa Chain A

Receptor sequence
>4rpaA (length=308) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
AKTYIFGHKNPDTDAISSAIIMAEFEQLRGNSGAKAYRLGDVSAETQFAL
DTFNVPAPELLTDDLDGQDVILVDHNEFQQSSDTIASATIKHVIDHHRIA
NFETAGPLCYRAEPVGCTATILYKMFRERGFEIKPEIAGLMLSAIISDSL
LFKSPTCTQQDVKAAEELKDIAKVDIQKYGLDMLKAGASTTDKSVEFLLN
MDAKSFTMGDYVTRIAQVNAVDLDEVLNRKEDLEKEMLAVSAQEKYDLFV
LVVTDIINSDSKILVVGAEKDKVGEAFNVQLEDDMAFLSGVVSRKKQIVP
QITEALTK
3D structure
PDB4rpa Structure of inorganic pyrophosphatase from Staphylococcus aureus reveals conformational flexibility of the active site.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D15 D75 H97 H98 D149 D14 D74 H96 H97 D148
BS02 MN A H9 D13 A16 D75 H8 D12 A15 D74
Gene Ontology
Molecular Function
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4rpa, PDBe:4rpa, PDBj:4rpa
PDBsum4rpa
PubMed25576794
UniProtP65752|PPAC_STAAM Probable manganese-dependent inorganic pyrophosphatase (Gene Name=ppaC)

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