Structure of PDB 4rno Chain A

Receptor sequence

>4rnoA (length=425) Species: 9606 (Homo sapiens)

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLGQPISADLLPSTYIEGLP
QGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSGIQTEWSPLTMLFLCATKFSAS

3D structure

• PDB: 4rno Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta.
• Chain: A
• Resolution: 2.82 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 G46 I47 I48 R61 S62 W64 K86 K293 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 G327	Q38 Y39 W42 G46 I47 I48 R61 S62 W64 K86 K287 P310 K311 T312 I313 G314 C315 S316 K317 N318 P320 G321
BS02	dna	A	S113 K224 S257 G259 G260 K261 L262 R377 S380 L381 R382 R383	S113 K218 S251 G253 G254 K255 L256 R371 S374 L375 R376 R377
BS03	DCP	A	D13 M14 C16 F17 F18 I48 Y52 R55 R61 D115 K231	D13 M14 C16 F17 F18 I48 Y52 R55 R61 D115 K225
BS04	CA	A	D13 M14 D115	D13 M14 D115

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4rno, PDBe:4rno, PDBj:4rno
• PDBsum: 4rno
• PubMed: 25666608
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)