Structure of PDB 4rn6 Chain A

Receptor sequence
>4rn6A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLF
RKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRT
RYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVC
LPDRETAASLLQAGYKGRVTGWGNLKETWTAPSVLQVVNLPIVERPVCKD
STRIRITDNMFCAGYKPDEGKRGDACEGDAGGPFVMKSPFNNRWYQMGIV
SWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
3D structure
PDB4rn6 Autoactivation of thrombin precursors.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 A195 G196
Catalytic site (residue number reindexed from 1) H74 D130 E227 G228 D229 A230 G231
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 15U A H57 Y60A W60D W148 W215 G216 H74 Y78 W81 W179 W252 G253 PDBbind-CN: -logKd/Ki=5.10,Kd=8uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rn6, PDBe:4rn6, PDBj:4rn6
PDBsum4rn6
PubMed23467412
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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