Structure of PDB 4rmh Chain A

Receptor sequence
>4rmhA (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
ERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYD
NKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKD
KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLS
WMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLL
LVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGGMDFDSKKA
YRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS
3D structure
PDB4rmh Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
ChainA
Resolution1.42 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P39 D40 F41 R42 N111 D113 H130
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F119 F235 V266 F62 F178 V209
BS02 ZN A C195 C200 C221 C224 C138 C143 C164 C167
BS03 3TE A F96 F119 F131 Y139 P140 F143 F190 I232 V233 F234 F41 F62 F74 Y82 P83 F86 F133 I175 V176 F177 BindingDB: IC50=>10000nM
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4rmh, PDBe:4rmh, PDBj:4rmh
PDBsum4rmh
PubMed25672491
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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