Structure of PDB 4rmc Chain A

Receptor sequence
>4rmcA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
EDMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPL
DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGA
IFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALRE
KVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGD
TPIDTFLMEMLEAP
3D structure
PDB4rmc Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V280 K284 L294 V298 R302 T449 F450 E453 V36 K40 L50 V54 R58 T205 F206 E209
BS02 3SV A A271 A272 Q275 F313 R316 L326 A327 C432 L436 A27 A28 Q31 F69 R72 L82 A83 C188 L192
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rmc, PDBe:4rmc, PDBj:4rmc
PDBsum4rmc
PubMed26331194
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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