Structure of PDB 4rlw Chain A

Receptor sequence
>4rlwA (length=153) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
VALSADIVGMHYRYPDHYEVEREKIREYAVAVQNDDAWYFEEDGAAELGY
KGLLAPLTFICVFGYKAQAAFFKHANIATAEAQIVQVDQVLKFEKPIVAG
DKLYCDVYVDSVREAHGTQIIVTKNIVTNEEGDLVQETYTTLAGRAGEGF
SDG
3D structure
PDB4rlw Molecular basis for the inhibition of beta-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors.
ChainA
Resolution2.196 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BUN A C61 G64 Y65 Q68 Q86 Q89 N125 T138 T140 L142 C61 G64 Y65 Q68 Q86 Q89 N125 T138 T140 L142 PDBbind-CN: -logKd/Ki=4.87,Kd=13.4uM
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016836 hydro-lyase activity
GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rlw, PDBe:4rlw, PDBj:4rlw
PDBsum4rlw
PubMed26081470
UniProtP9WFK1|Y635_MYCTU UPF0336 protein Rv0635 (Gene Name=Rv0635)

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