Structure of PDB 4rlp Chain A

Receptor sequence
>4rlpA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKRNILEEV
KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLA
EISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESGTIEYMA
PEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN
LPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELL
ARKVEPPFKPL
3D structure
PDB4rlp Development of Organometallic S6K1 Inhibitors.
ChainA
Resolution2.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D218 K220 E222 N223 D236 T256
Catalytic site (residue number reindexed from 1) D118 K120 E122 N123 D136 T145
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 72B A L97 G98 K99 G100 V105 A121 L172 Y174 L175 E179 E222 M225 T235 L13 G14 K15 G16 V21 A37 L72 Y74 L75 E79 E122 M125 T135 PDBbind-CN: -logKd/Ki=8.14,IC50=7.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rlp, PDBe:4rlp, PDBj:4rlp
PDBsum4rlp
PubMed25356520
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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