Structure of PDB 4rlo Chain A

Receptor sequence
>4rloA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAERNILE
EVKHPFIVDLIYAFQTKLYLILEYLSGGELFMQLEREGIFMEDTACFYLA
EISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKEGTIEYMAP
EILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNL
PPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLA
RKVEPPFKP
3D structure
PDB4rlo Development of Organometallic S6K1 Inhibitors.
ChainA
Resolution2.527 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D218 K220 E222 N223 D236 T256
Catalytic site (residue number reindexed from 1) D118 K120 E122 N123 D136 T144
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3T3 A L97 G98 K99 G100 V105 A121 L172 Y174 L175 E179 E222 M225 L13 G14 K15 G16 V21 A37 L72 Y74 L75 E79 E122 M125
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rlo, PDBe:4rlo, PDBj:4rlo
PDBsum4rlo
PubMed25356520
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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