Structure of PDB 4rkz Chain A

Receptor sequence
>4rkzA (length=313) Species: 273075 (Thermoplasma acidophilum DSM 1728) [Search protein sequence]
TYRSIGSTAYPTIGVVLLGGIANPVTRTPLHTSAGIAYSDSCGSIRSETR
IYADEATHIYFNGTESTSVRRVLDRYSSVFEEAFGTKTVSYSSQNFGILS
GSSDAGAASIGAAILGLKPDLDPHDVENDLRAVSESAGRSLFGGLTITWS
DGFHAYTEKILDPEAFSGYSIVAFAFDYQRNPSDVIHQNIVRSDLYPARK
KHADEHAHMIKEYAKTNDIKGIFDLAQEDTEEYHSILRGVGVNVIRENMQ
KLISYLKLIRKDYWNAYIVTGGSNVYVAVESENADRLFSIENTFGSKKKM
LRIVGGAWHRRPE
3D structure
PDB4rkz Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.185: mevalonate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A F62 Y96 S98 N100 S105 G106 S107 S108 G111 R185 S188 F61 Y91 S93 N95 S100 G101 S102 S103 G106 R180 S183
BS02 3S4 A G15 L19 S105 E140 R144 H192 T275 G14 L18 S100 E135 R139 H187 T270
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4rkz, PDBe:4rkz, PDBj:4rkz
PDBsum4rkz
PubMed25422158
UniProtQ9HIN1|MV3K_THEAC Mevalonate 3-kinase (Gene Name=Ta1305)

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