Structure of PDB 4rh5 Chain A

Receptor sequence
>4rh5A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
DTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYK
DVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ
FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSE
DCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPAHGVPDDSSDFLEFVNY
VRSLRVDSEPVLVHSSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKM
RDQRAMMVQTSSQYKFVCEAILRVYEEGLV
3D structure
PDB4rh5 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A811 S842 R848 T849 Q886
Catalytic site (residue number reindexed from 1) A184 S215 R221 T222 Q259
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D672 Y676 D678 H812 S842 S843 A844 I846 G847 R848 Q886 D45 Y49 D51 H185 S215 S216 A217 I219 G220 R221 Q259
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rh5, PDBe:4rh5, PDBj:4rh5
PDBsum4rh5
PubMed25728925
UniProtP26045|PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (Gene Name=PTPN3)

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