Structure of PDB 4rgb Chain A

Receptor sequence
>4rgbA (length=274) Species: 243243 (Mycobacterium avium 104) [Search protein sequence]
GSLDGRVVFITGAARGQGRSHAVMCAEQGANIVGVDICEDIDIVPYKLGT
YEELEETARLVEKTGQEMLFRKADVRDKAVLQEVFDAGVEQFGHIDTVIA
NAGVVLTNPDERDASEALRLGLDIMLIGVWNTFQVAIPHMKERGQGGNLI
ATSSMIALLDLTDGRGGTDAYLTSKLAITGLVRSYALMLAADRIRVNGVA
PTNCSTPMITENPALFKVIEENPHLVNAMSTALPDFPMIEPRDVSNAILF
LISDAGRSFTGSVLKVDAGMDVKR
3D structure
PDB4rgb Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G31 S169 L173 Y186 K190
Catalytic site (residue number reindexed from 1) G16 S154 L158 Y171 K175
Enzyme Commision number 1.1.1.275: (+)-trans-carveol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G27 R30 G31 Q32 D51 I52 G64 D89 V90 N116 A117 G118 T167 S169 Y186 K190 N218 C219 T221 M223 I224 G12 R15 G16 Q17 D36 I37 G49 D74 V75 N101 A102 G103 T152 S154 Y171 K175 N203 C204 T206 M208 I209
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0033702 (+)-trans-carveol dehydrogenase activity

View graph for
Molecular Function
External links
PDB RCSB:4rgb, PDBe:4rgb, PDBj:4rgb
PDBsum4rgb
PubMed28120876
UniProtA0A0H2ZU39

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