Structure of PDB 4rea Chain A

Receptor sequence
>4reaA (length=590) Species: 9606 (Homo sapiens) [Search protein sequence]
EFPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVR
LFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLE
LLSAPELKSLAKTFHLVNPNGQKQQLVDAFLKLAKQGIGAVILKRAKALA
GQSVRICKGPRAVFSRILLLFSLTDSMELLVNLGRMEFPSYTINRKTHIF
QDRDDLIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNHPS
LRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQ
RIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRTGHRLSL
YQRAVRLRESPSCKKFKHLFQQLPEMAVQDVKHVTITGRLCLCSVEELAL
AHYRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLD
LCTDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVASLVSW
DRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPALVVWNSQSR
HFKLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVAV
3D structure
PDB4rea Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer.
ChainA
Resolution3.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.-
3.1.4.1: phosphodiesterase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A N452 S460 N82 S90
BS02 dna A E398 K401 E28 K31
BS03 dna A E390 K406 Q409 E20 K36 Q39
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4rea, PDBe:4rea, PDBj:4rea
PDBsum4rea
PubMed25500724
UniProtQ9Y2M0|FAN1_HUMAN Fanconi-associated nuclease 1 (Gene Name=FAN1)

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