Structure of PDB 4re8 Chain A

Receptor sequence
>4re8A (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
ANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLS
GSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGK
LIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVL
ITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGASCLSRLLGKLPELRTL
CTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
3D structure
PDB4re8 Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity
ChainA
Resolution2.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3MJ A L162 L175 L178 T182 Q197 L224 K227 L228 L132 L145 L148 T152 Q167 L190 K193 L194
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4re8, PDBe:4re8, PDBj:4re8
PDBsum4re8
PubMed26235054
UniProtP22736|NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (Gene Name=NR4A1)

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