Structure of PDB 4rdr Chain A

Receptor sequence

>4rdrA (length=706) Species: 122586 (Neisseria meningitidis MC58)

SRPRATSGLLHTSTASDKIISGDTLRQKAVNLGDALDGVPGIHASQYGGG
ASAPVIRGQTGRRIKVLNHHGETGDMADFSPDHAIMVDTALSQQVEILRG
PVTLLYSSGNVAGLVDVADGKIPEKMPENGVSGELGLRLSSGNLEKLTSG
GINIGLGKNFVLHTEGLYRKSGDYAVPRYRNLKRLPDSHADSQTGSIGLS
WVGEKGFIGVAYSDRRDQYGLPAHSHEYDDCHADIIWQKSLINKRYLQLY
PHLLTEEDIDYDNPGLSCGHSGRPWIDLRNKRYELRAEWKQPFPGFEALR
VHLNRNDYRHDEKAGDAVENFFNNQTQNARIELRHQPIGRLKGSWGVQYL
QQKSSALSAISEAVKQPMLLDNKVQHYSFFGVEQANWDNFTLEGGVRVEK
QKASIQYDKALIDRENYYNHPLPDLGAHRQTARSFALSGNWYFTPQHKLS
LTASHQERLPSTQELYAHGKHVATNTFEVGNKHLNKERSNNIELALGYEG
DRWQYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMKLVRYNQSGADF
YGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQD
DQNAPRVPAARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHH
MLNLGANYRRNTRYGEWNWYVKADNLLNQSVYAHSSFLSDTPQMGRSFTG
GVNVKF

3D structure

• PDB: 4rdr The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD.
• Chain: A
• Resolution: 2.472 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D99 H100 E340 H499	D82 H83 E312 H471
BS02	C8E	A	T165 Q210 T211 D231 R233 R307	T148 Q193 T194 D214 R216 R279
BS03	C8E	A	G599 D600 Y601 A638 F662	G571 D572 Y573 A610 F634
BS04	C8E	A	F418 G467 W469 L479	F390 G439 W441 L451

Gene Ontology

Molecular Function

• GO:0015344 siderophore uptake transmembrane transporter activity
• GO:0046872 metal ion binding

Biological Process

• GO:0033214 siderophore-dependent iron import into cell
• GO:0044718 siderophore transmembrane transport

Cellular Component

• GO:0009279 cell outer membrane

External links

• PDB: RCSB:4rdr, PDBe:4rdr, PDBj:4rdr
• PDBsum: 4rdr
• PubMed: 26282243
• UniProt: Q9JZN9|Y964_NEIMB Probable TonB-dependent receptor NMB0964 (Gene Name=NMB0964)