Structure of PDB 4rcp Chain A

Receptor sequence
>4rcpA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITPREGLPYLRTWFRTRSAIILHLS
NGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKEL
ASRLRYARTMVDKLLSSRSASNR
3D structure
PDB4rcp A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K413 W414 D416 Y417 Y421 Y481 F482 Y485 L490 L491 H538 K540 K42 W43 D45 Y46 Y50 Y110 F111 Y114 L119 L120 H162 K164
External links
PDB RCSB:4rcp, PDBe:4rcp, PDBj:4rcp
PDBsum4rcp
PubMed25347203
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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