Structure of PDB 4rak Chain A

Receptor sequence
>4rakA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
VQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQR
FAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA
RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDD
AEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR
FPRMLMKLVSLRTLSSVHSEQVFALRKLPPLLSEIW
3D structure
PDB4rak Liver X Receptor (LXR) partial agonists: Biaryl pyrazoles and imidazoles displaying a preference for LXR beta.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 652 A F271 T272 L274 A275 S278 M312 T316 R319 F329 L330 L345 I353 F54 T55 L57 A58 S61 M95 T99 R102 F112 L113 L128 I136 MOAD: Ki=14nM
PDBbind-CN: -logKd/Ki=7.85,Ki=14nM
BindingDB: EC50=250nM,Ki=14nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function

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Biological Process
External links
PDB RCSB:4rak, PDBe:4rak, PDBj:4rak
PDBsum4rak
PubMed25435151
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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