Structure of PDB 4r8m Chain A

Receptor sequence
>4r8mA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
KERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLY
DNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELGQFKPTICHYFMRLLK
DKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPL
SWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDL
LLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQGMDFDSKKAYRDVA
WLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ
3D structure
PDB4r8m Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P40 D41 F42 R43 N112 D114 H131
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H187 V233 F235 G236 E237 V266 Q267 H131 V177 F179 G180 E181 V210 Q211
BS02 ZN A C195 C200 C221 C224 C139 C144 C165 C168
BS03 3LX A F119 H187 F190 F65 H131 F134
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4r8m, PDBe:4r8m, PDBj:4r8m
PDBsum4r8m
PubMed25704306
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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