Structure of PDB 4r8i Chain A

Receptor sequence
>4r8iA (length=68) Species: 9606 (Homo sapiens) [Search protein sequence]
DAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEIC
ADPKQKWVQDSMDHLDKQ
3D structure
PDB4r8i Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A N17 R18 K19 I20 S21 V22 Q23 R24 K49 W59 H66 N15 R16 K17 I18 S19 V20 Q21 R22 K47 W57 H64
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0031727 CCR2 chemokine receptor binding
GO:0048020 CCR chemokine receptor binding
Biological Process
GO:0001525 angiogenesis
GO:0002548 monocyte chemotaxis
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007259 cell surface receptor signaling pathway via JAK-STAT
GO:0008360 regulation of cell shape
GO:0009617 response to bacterium
GO:0009887 animal organ morphogenesis
GO:0019079 viral genome replication
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0019725 cellular homeostasis
GO:0030335 positive regulation of cell migration
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035684 helper T cell extravasation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043615 astrocyte cell migration
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0050870 positive regulation of T cell activation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to type II interferon
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090280 positive regulation of calcium ion import
GO:1904783 positive regulation of NMDA glutamate receptor activity
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000427 positive regulation of apoptotic cell clearance
GO:2000502 negative regulation of natural killer cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r8i, PDBe:4r8i, PDBj:4r8i
PDBsum4r8i
PubMed25901662
UniProtP13500|CCL2_HUMAN C-C motif chemokine 2 (Gene Name=CCL2)

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