Structure of PDB 4r8a Chain A

Receptor sequence
>4r8aA (length=538) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
LPEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALLVR
MVMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFGLL
KKDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPVYE
LRCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFRLR
ADVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLFQF
AQHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALAREAS
CAPESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSEPC
SVEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHPFH
SAPADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSPFV
YWELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWPAQ
RRYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYV
3D structure
PDB4r8a Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4r8a, PDBe:4r8a, PDBj:4r8a
PDBsum4r8a
PubMed25319828
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

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