Structure of PDB 4r6x Chain A

Receptor sequence
>4r6xA (length=258) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
SDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSK
VLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEA
NDILTKEFPENNFDLIYSRAAILHLSLENKNKLFQKCYKWLKPTGTLLIT
DYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSD
YWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRW
GYFKATKN
3D structure
PDB4r6x An Alternative Mechanism for the Methylation of Phosphoethanolamine Catalyzed by Plasmodium falciparum Phosphoethanolamine Methyltransferase.
ChainA
Resolution2.5534 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.103: phosphoethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OPE A Y27 I36 Y160 Y175 R179 Y181 K247 Y19 I28 Y152 Y167 R171 Y173 K239
BS02 SAH A Y19 Y35 I36 S37 G63 S64 D85 I86 D110 I111 R127 A128 A129 H132 Y11 Y27 I28 S29 G55 S56 D77 I78 D102 I103 R119 A120 A121 H124 PDBbind-CN: -logKd/Ki=5.27,Kd=5.4uM
Gene Ontology
Molecular Function
GO:0000234 phosphoethanolamine N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0009058 biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4r6x, PDBe:4r6x, PDBj:4r6x
PDBsum4r6x
PubMed25288796
UniProtQ8IDQ9|PMT_PLAF7 Phosphoethanolamine N-methyltransferase (Gene Name=PMT)

[Back to BioLiP]