Structure of PDB 4r6v Chain A

Receptor sequence
>4r6vA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
DPLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDQA
STVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY
VILECAAKGNLREFLRARRPPGPLSFPVLVSCAYQVARGMQYLESRKCIH
RDLAARNVLVTEDNVMKIADFGLAPVKWMAPEALFDEVYTHQSDVWSFGI
LLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWH
AAPSQRPTFKQLVEALDKVLLAV
3D structure
PDB4r6v Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
ChainA
Resolution2.353 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 A614 R616 N617 D630
Catalytic site (residue number reindexed from 1) D152 A154 R156 N157 D170
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FI3 A L473 G474 E475 C477 F478 K503 E520 I534 L550 C552 A553 G556 E560 L619 A629 D630 F631 L31 G32 E33 C35 F36 K56 E73 I87 L103 C105 A106 G109 E113 L159 A169 D170 F171 PDBbind-CN: -logKd/Ki=7.45,IC50=35.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4r6v, PDBe:4r6v, PDBj:4r6v
PDBsum4r6v
PubMed25349422
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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