Structure of PDB 4r6s Chain A

Receptor sequence
>4r6sA (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDM
NSLMMGEDKIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQ
VTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFM
EPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLL
QALELQLKLNHPESSQLFAKLLQKMTDLRQIVFEHVQLLQVIKKTETDMS
LHPLLQEIYKDL
3D structure
PDB4r6s Pharmacological repression of PPAR gamma promotes osteogenesis.
ChainA
Resolution2.301 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3K2 A I281 F282 C285 Q286 R288 S289 Y327 L330 I341 S342 H449 L453 Y473 I67 F68 C71 Q72 R74 S75 Y113 L116 I127 S128 H235 L239 Y259 BindingDB: EC50=503nM,IC50=2.0nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r6s, PDBe:4r6s, PDBj:4r6s
PDBsum4r6s
PubMed26068133
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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