Structure of PDB 4r6a Chain A

Receptor sequence
>4r6aA (length=746) Species: 9606 (Homo sapiens) [Search protein sequence]
SRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITN
ESFQGLQNLTKINLNHNPNVNGLNITDGAFLNLKNLRELLLEDNQLPQIP
SGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTN
IEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEED
FKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRY
LNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEI
LDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLM
QLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLFEFDPHSN
FYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANS
NAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSH
YFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFS
GNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASL
TELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRT
LLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSATKLSMLELHGN
PFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE
3D structure
PDB4r6a Hybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A D462 H464 D396 H398
BS02 HB2 A D543 G572 V573 T574 D477 G506 V507 T508 BindingDB: EC50=100nM
BS03 HB2 A Y348 V378 F405 Y307 V337 F364 BindingDB: EC50=100nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r6a, PDBe:4r6a, PDBj:4r6a
PDBsum4r6a
PubMed
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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