Structure of PDB 4r5x Chain A

Receptor sequence
>4r5xA (length=888) Species: 186763 (Plasmodium falciparum FcB1/Columbia) [Search protein sequence]
KIHYRKDYKPSGFIINQVTLNINIHDQETIVRSVLDMDISKHNVGEDLVF
DGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVII
HPETNYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTAD
KEKYPVLLSNGDKVNEFEIPGGRHGARFNDPPLKPCYLFAVVAGDLKHLS
ATYITKYTKKKVELYVFSEEKYVSKLQWALECLKKSMAFDEDYFGLEYDL
SRLNLVAVSDFNVGAMENKGLNIFNANSLLASKKNSIDFSYARILTVVGH
EYFHQYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTRLSHVDL
LRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGE
EYYKKGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWF
SQSGTPHVSFKYNYDAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLI
NPENGKEMISQTTLELTKESDTFVFNNIAVKPIPSLFRGFSAPVYIEDQL
TDEERILLLKYDSDAFVRYNSCTNIYMKQILMNYNEFLKAKNEKLESFQL
TPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNLDTDVLA
DTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRT
LRNTLLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELY
DKTYKLSKDDELLLQEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDI
RAVYLPFTNNLRRFHDISGKGYKLIAEVITKTDKFNPMVATQLCEPFKLW
NKLDTKRQELMLNEMNTMLQEPQISNNLKEYLLRLTNK
3D structure
PDB4r5x Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E463 H496 E497 H500 E519 E572 Y580
Catalytic site (residue number reindexed from 1) E267 H300 E301 H304 E323 E376 Y384
Enzyme Commision number 3.4.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H496 H500 E519 H300 H304 E323
BS02 R5X A E319 V459 G460 A461 M462 R489 H496 E497 H500 E519 Y575 Y580 M1034 E123 V263 G264 A265 M266 R293 H300 E301 H304 E323 Y379 Y384 M838 MOAD: Ki=5.5uM
PDBbind-CN: -logKd/Ki=5.26,Ki=5.5uM
BindingDB: Ki=5.5nM
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4r5x, PDBe:4r5x, PDBj:4r5x
PDBsum4r5x
PubMed25299353
UniProtO96935|AMPN_PLAF7 Aminopeptidase N (Gene Name=M1AAP)

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