Structure of PDB 4r5f Chain A

Receptor sequence
>4r5fA (length=369) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence]
AYFDYTSAKPVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREK
VAKLVNGGGGTVVFTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSV
INPAKFLQKQGFEVEYIPVGKYGEVDVSFIDQKLRDDTILVSVQHANNEI
GTIQPVEEISEVLAGKAALHIDATASVGQIEVDVEKIGADMLTISSNKIY
GPKGVGALWIRKEAKLQPVILGGGQENGLRSGSENVPSIVGFGKAAEITA
MEWREEAERLRRLRDRIIDNVLKIEESYLNGHPEKRLPNNVNVRFSYIEG
ESIVLSLDMAGIQASTGQPSHVLMACGLKHEEAHGTLLLTLGRYNTDEDV
DRLLEVLPGVIERLRSMSP
3D structure
PDB4r5f IscS from Archaeoglobus fulgidus has no desulfurase activity but may provide a cysteine ligand for [Fe2S2] cluster assembly.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H98 D173 A176 K199
Catalytic site (residue number reindexed from 1) H97 D172 A175 K198
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A H98 D173 T175 H97 D172 T174
BS02 PMP A A69 T70 H98 N149 D173 T175 K199 A68 T69 H97 N148 D172 T174 K198
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0016226 iron-sulfur cluster assembly
GO:0044571 [2Fe-2S] cluster assembly
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4r5f, PDBe:4r5f, PDBj:4r5f
PDBsum4r5f
PubMed25447670
UniProtO29689|ISCS2_ARCFU Cysteine desulfurase IscS 2 (Gene Name=iscS2)

[Back to BioLiP]