Structure of PDB 4r4t Chain A

Receptor sequence
>4r4tA (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMVGQLSRGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSD
GLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILME
LEVLKSAEAVGVKIGNPVPYNE
3D structure
PDB4r4t Diphenylpyrazoles as replication protein a inhibitors.
ChainA
Resolution1.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3J0 A I33 T34 R41 R43 S55 M57 A59 T60 V93 I95 I35 T36 R43 R45 S57 M59 A61 T62 V95 I97 PDBbind-CN: -logKd/Ki=6.26,Kd=0.55uM
BindingDB: Kd=0.550000nM
Gene Ontology
Biological Process
GO:0006260 DNA replication
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r4t, PDBe:4r4t, PDBj:4r4t
PDBsum4r4t
PubMed25699140
UniProtP27694|RFA1_HUMAN Replication protein A 70 kDa DNA-binding subunit (Gene Name=RPA1)

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