Structure of PDB 4r4o Chain A

Receptor sequence

>4r4oA (length=123) Species: 9606 (Homo sapiens)

GSHMVGQLSRGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMS
DGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILM
ELEVLKSAEAVGVKIGNPVPYNE

3D structure

• PDB: 4r4o Diphenylpyrazoles as replication protein a inhibitors.
• Chain: A
• Resolution: 1.33 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3HW	A	I33 R41 R43 S55 M57 A59 N85 V93 M97	I36 R44 R46 S58 M60 A62 N88 V96 M100	PDBbind-CN: -logKd/Ki=5.82,Kd=1.5uM BindingDB: Kd=1.5nM

Gene Ontology

Molecular Function

• GO:0003677 DNA binding

Biological Process

• GO:0006260 DNA replication

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4r4o, PDBe:4r4o, PDBj:4r4o
• PDBsum: 4r4o
• PubMed: 25699140
• UniProt: P27694|RFA1_HUMAN Replication protein A 70 kDa DNA-binding subunit (Gene Name=RPA1)