Structure of PDB 4r4i Chain A

Receptor sequence
>4r4iA (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMVGQLSRGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMS
DGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILM
ELEVLKSAEAVGVKIGNPVPYNE
3D structure
PDB4r4i Diphenylpyrazoles as replication protein a inhibitors.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3HV A R31 I33 T34 R41 R43 S55 A59 T60 N85 I95 R34 I36 T37 R44 R46 S58 A62 T63 N88 I98 PDBbind-CN: -logKd/Ki=6.27,Kd=0.54uM
BindingDB: Kd=0.540000nM
Gene Ontology
Biological Process
GO:0006260 DNA replication
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r4i, PDBe:4r4i, PDBj:4r4i
PDBsum4r4i
PubMed25699140
UniProtP27694|RFA1_HUMAN Replication protein A 70 kDa DNA-binding subunit (Gene Name=RPA1)

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