Structure of PDB 4r2r Chain A

Receptor sequence

>4r2rA (length=88) Species: 9606 (Homo sapiens) [Search protein sequence]

SEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHL
KTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ

3D structure

PDB

4r2r Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.

Chain

Resolution

2.089 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R362 F364 R366 Q369 R372 H373 R376 R390 R394 H397 H401 T404 R424 R430	R14 F16 R18 Q21 R24 H25 R28 R42 R46 H49 H53 T56 R76 R82
BS02	dna	A	D368 D396 K399 S425	D20 D48 K51 S77
BS03	ZN	A	C355 C360 H373 H377	C7 C12 H25 H29
BS04	ZN	A	C385 C388 H401 H405	C37 C40 H53 H57
BS05	ZN	A	C413 C418 H431 H435	C65 C70 H83 H87

External links

PDB	RCSB:4r2r, PDBe:4r2r, PDBj:4r2r
PDBsum	4r2r
PubMed	25258363
UniProt	P19544\|WT1_HUMAN Wilms tumor protein (Gene Name=WT1)