Structure of PDB 4r2e Chain A

Receptor sequence

>4r2eA (length=88) Species: 9606 (Homo sapiens)

EKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLK
THTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR

3D structure

• PDB: 4r2e Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
• Chain: A
• Resolution: 1.84 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R362 F364 R366 Q369 R372 H373 R376 R390 R394 H397 H401 T404 R424 R430	R13 F15 R17 Q20 R23 H24 R27 R41 R45 H48 H52 T55 R75 R81
BS02	dna	A	D396 S425 D426	D47 S76 D77
BS03	ZN	A	C355 C360 H373 H377	C6 C11 H24 H28
BS04	ZN	A	C385 C388 H401 H405	C36 C39 H52 H56
BS05	ZN	A	C413 C418 H431 H435	C64 C69 H82 H86

External links

• PDB: RCSB:4r2e, PDBe:4r2e, PDBj:4r2e
• PDBsum: 4r2e
• PubMed: 25258363
• UniProt: P19544|WT1_HUMAN Wilms tumor protein (Gene Name=WT1)