Structure of PDB 4r2a Chain A

Receptor sequence
>4r2aA (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]
ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLT
THIRTHTGEKPFACDICGRKFARSDERKRHTKIHLR
3D structure
PDB4r2a Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
ChainA
Resolution1.591 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R351 E354 R357 H358 I361 R375 S378 R379 H382 H386 T389 R407 R413 R17 E20 R23 H24 I27 R41 S44 R45 H48 H52 T55 R73 R79
BS02 dna A D381 S408 K412 D47 S74 K78
BS03 ZN A C340 C345 H358 H362 C6 C11 H24 H28
BS04 ZN A C370 C373 H386 H390 C36 C39 H52 H56
BS05 ZN A C398 C401 H414 H418 C64 C67 H80 H84
External links
PDB RCSB:4r2a, PDBe:4r2a, PDBj:4r2a
PDBsum4r2a
PubMed25258363
UniProtP18146|EGR1_HUMAN Early growth response protein 1 (Gene Name=EGR1)

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