Structure of PDB 4r21 Chain A

Receptor sequence
>4r21A (length=422) Species: 7955 (Danio rerio) [Search protein sequence]
NLPPHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAG
RPKMVTTDLLTQGGKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTI
VQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSSSYQPSDPEL
QTVIQYNDGIVQTIARGGLVDIKDLKRLKECVSIRDQLLYKKLLEHKKSL
TPGEPRDLLDALLIGQQRGSGGADDITEDHVLMTAAEAFGAGVETTSTTL
LWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVM
RIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQ
FNPERFLESSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSLP
DLQGRFGVVLQPERYTVTVTPR
3D structure
PDB4r21 Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T306 F433 C440
Catalytic site (residue number reindexed from 1) T245 F364 C371
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A R103 A120 A302 G303 T306 T307 L370 H373 P432 F433 R438 C440 V441 G442 R51 A68 A241 G242 T245 T246 L309 H312 P363 F364 R369 C371 V372 G373
BS02 STR A F121 G301 I371 F69 G240 I310
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:4r21, PDBe:4r21, PDBj:4r21
PDBsum4r21
PubMed25533464
UniProtA7U483

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