Structure of PDB 4r12 Chain A

Receptor sequence
>4r12A (length=573) Species: 5786 (Dictyostelium purpureum) [Search protein sequence]
YTTLYSSYPCTKIMTSDGQFGCSSKHGGNSGILYLIDDDESYNNYFSYSQ
QKDIIVVLDTNYFNSTSVLNLHNKSKIEGIIVLTDTKKTYPYSPDSRYPN
KIYGLYPNSNLEWNPNADGFTYFSFPFPIFAIDNQTSVAIRNVSKHNRDG
QYPAWGAELDSFMQGAINSETCLRRGFCEPVGGQSIWSSFSSKIDKEKEI
ILVMLPFDTTAFFRDLSIGADQSSFATVTLLSVIKSLAAVDRSSWNKEVV
FAFWNAERWGYVGSEYFINDLLNFQCKTYNSDKSKCIDPPRADLAFQTQI
NFTKISTIIELNQIGRAQLDKNLGKYSLYLHTAGTKTSSVTDILDQVASS
YENSTITFKPTTQTELPPSSSMSFLKKTNKIPVVVITDHDYKYSNPYYGY
EQDDNENVLGSTLNDIVYILSTFIDRIAGGNNNITIDKNFINILYPCFTS
SITCFNILMKTYPLNEVPNFYSSVFGTSLTTTLSPYETKLIHRLLYSITQ
YNSTLTNCTSDNDCPSSLCYSGQCVSSNTHLHNALSLGFDFDTSKNVWKI
VNSSYPIFTESNWDYTALKVFKI
3D structure
PDB4r12 Crystal structure of the gamma-secretase component nicastrin.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D543 C546 S549 D511 C514 S517
Gene Ontology
Biological Process
GO:0016485 protein processing
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:4r12, PDBe:4r12, PDBj:4r12
PDBsum4r12
PubMed25197054
UniProtF0ZBA6|NICA_DICPU Nicastrin (Gene Name=ncstn)

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