Structure of PDB 4r07 Chain A

Receptor sequence
>4r07A (length=747) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYPCDEKVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGL
QNLTKINLNHNPNVNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPES
LTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVF
ETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLIN
LTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSST
SLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN
YIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLS
TINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPTDFEFDPHSNFYHFT
RPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVL
SGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIA
GVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLD
ILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHI
NDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH
NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHG
NPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE
3D structure
PDB4r07 Toll-like receptor 8 senses degradation products of single-stranded RNA
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A D462 H464 D391 H393
BS02 URI A Y348 K350 G351 Y353 V378 F405 R429 Y301 K303 G304 Y306 V331 F358 R382 MOAD: Kd=55uM
BS03 UCG A K314 V315 E340 I341 D343 H373 R375 H469 T471 R472 P473 L474 K267 V268 E293 I294 D296 H326 R328 H398 T400 R401 P402 L403 MOAD: Kd=4.8uM
PDBbind-CN: -logKd/Ki=5.32,Kd=4.8uM
BS04 URI A D543 D545 V573 T574 D472 D474 V502 T503 MOAD: Kd=55uM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r07, PDBe:4r07, PDBj:4r07
PDBsum4r07
PubMed25599397
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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