Structure of PDB 4qxq Chain A

Receptor sequence
>4qxqA (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
SVAHGLAWAYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQR
AGTCVLEYATPLITLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAP
ESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQ
3D structure
PDB4qxq Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1YE A A162 Y163 Y167 T263 T267 A9 Y10 Y14 T110 T114 MOAD: Kd=1.99uM
PDBbind-CN: -logKd/Ki=5.70,Kd=1.99uM
BS02 1YE A G166 I235 R238 G13 I82 R85 MOAD: Kd=1.99uM
PDBbind-CN: -logKd/Ki=5.70,Kd=1.99uM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4qxq, PDBe:4qxq, PDBj:4qxq
PDBsum4qxq
PubMed25199835
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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