Structure of PDB 4qxc Chain A

Receptor sequence
>4qxcA (length=329) Species: 10090 (Mus musculus) [Search protein sequence]
RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
3D structure
PDB4qxc A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R36 N114 T115 Q116 K117 G118 I144 S145 N186 A187 I188 Y199 T209 D214 F215 V220 Q253 G254 N298 K323 F324 R325 R1 N79 T80 Q81 K82 G83 I109 S110 N151 A152 I153 Y164 T174 D179 F180 V185 Q218 G219 N263 K288 F289 R290
External links
PDB RCSB:4qxc, PDBe:4qxc, PDBj:4qxc
PDBsum4qxc
PubMed25128496
UniProtP59997|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)

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