Structure of PDB 4qx8 Chain A

Receptor sequence

>4qx8A (length=329) Species: 10090 (Mus musculus) [Search protein sequence]

RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME

3D structure

PDB

4qx8 A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.

Chain

Resolution

1.65 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	M111 Q116 I144 S145 N186 A187 I188 Y199 L201 T209 D214 F215 V220 N298 V320 K323 F324 R325	M76 Q81 I109 S110 N151 A152 I153 Y164 L166 T174 D179 F180 V185 N263 V285 K288 F289 R290
BS02	AKG	A	I144 T209 H212 D214 Y222 K229 H284 V286	I109 T174 H177 D179 Y187 K194 H249 V251

External links

PDB	RCSB:4qx8, PDBe:4qx8, PDBj:4qx8
PDBsum	4qx8
PubMed	25128496
UniProt	P59997\|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)

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