Structure of PDB 4qvx Chain A

Receptor sequence
>4qvxA (length=136) Species: 9606 (Homo sapiens) [Search protein sequence]
SQSNRELVVDFLSYKLSQKGYGMAAVKQALREAGDEFELRYRRAFSDLTS
QLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKKMQ
VLVSRIAAWMATYLNDHLEPWIQENGGWATFVELYG
3D structure
PDB4qvx Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3CQ A E96 F97 Y101 R102 F105 S106 L108 N136 G138 R139 A142 S145 F146 A149 Y195 E36 F37 Y41 R42 F45 S46 L48 N76 G78 R79 A82 S85 F86 A89 Y135 MOAD: Ki<0.01nM
PDBbind-CN: -logKd/Ki=11.00,Ki<0.01nM
BindingDB: Ki=<0.010000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4qvx, PDBe:4qvx, PDBj:4qvx
PDBsum4qvx
PubMed25313317
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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