Structure of PDB 4qtd Chain A

Receptor sequence
>4qtdA (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIK
KLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVY
IVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS
NIVVKSDCTLKILDFGLARTSFMMTPYVVTRYYRAPEVILGMGYKENVDL
WSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRT
YVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASK
RISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYK
EVMDL
3D structure
PDB4qtd A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D146 K148 N151 D164 T180
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38Z A V40 A53 M108 L110 M111 D112 A113 N114 C116 Q117 Q120 S155 N156 L168 V35 A48 M103 L105 M106 D107 A108 N109 C111 Q112 Q115 S150 N151 L163 MOAD: ic50=1080nM
PDBbind-CN: -logKd/Ki=5.97,IC50=1080nM
BS02 ANP A G35 A36 Q37 K153 S155 N156 T188 G30 A31 Q32 K148 S150 N151 T180
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qtd, PDBe:4qtd, PDBj:4qtd
PDBsum4qtd
PubMed25195011
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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