Structure of PDB 4qtc Chain A

Receptor sequence
>4qtcA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
QKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGP
DLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGS
YPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTK
LSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYT
LNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQ
FDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMK
QIKRKIQEFHRTMLNFSSATDLLCQHSLFK
3D structure
PDB4qtc A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38Z A I490 G491 E492 A509 Y580 G585 S586 A587 G608 L656 I686 I22 G23 E24 A41 Y112 G117 S118 A119 G140 L188 I218 MOAD: Kd=0.297uM
PDBbind-CN: -logKd/Ki=6.40,IC50=398nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qtc, PDBe:4qtc, PDBj:4qtc
PDBsum4qtc
PubMed25195011
UniProtQ8TF76|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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