Structure of PDB 4qt2 Chain A

Receptor sequence
>4qt2A (length=122) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
FEKVELTADGGVIKTILKKGDEGEENIPKKGNEVTVHYVGKLESTGKVFD
SSFDRNVPFKFHLEQGEVIKGWDICVSSMRKNEKCLVRIESMYGYGDEGC
GESIPGNSVLLFEIELLSFREL
3D structure
PDB4qt2 Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution
ChainA
Resolution1.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y44 F55 D56 I75 Y101 F118
Catalytic site (residue number reindexed from 1) Y38 F49 D50 I69 Y95 F112
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAP A Y44 D56 F65 G72 E73 V74 I75 W78 Y101 Y38 D50 F59 G66 E67 V68 I69 W72 Y95 MOAD: ic50=0.48uM
PDBbind-CN: -logKd/Ki=6.32,IC50=0.48uM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:4qt2, PDBe:4qt2, PDBj:4qt2
PDBsum4qt2
PubMed26057671
UniProtQ8I4V8|FKB35_PLAF7 Peptidyl-prolyl cis-trans isomerase FKBP35 (Gene Name=FKBP35)

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