Structure of PDB 4qsy Chain A

Receptor sequence
>4qsyA (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
RWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHI
KIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNC
3D structure
PDB4qsy Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A V14 R32 S34 K35 S36 T42 T52 H53 I54 K55 L65 G67 G68 K89 E90 K91 I96 V10 R28 S30 K31 S32 T38 T48 H49 I50 K51 L61 G63 G64 K85 E86 K87 I92
External links
PDB RCSB:4qsy, PDBe:4qsy, PDBj:4qsy
PDBsum4qsy
PubMed
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

[Back to BioLiP]