Structure of PDB 4qs7 Chain A

Receptor sequence
>4qs7A (length=455) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
WGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLIS
YVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPP
HLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQT
SLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVG
TLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINM
EWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLK
MAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILE
VPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDEVQKSVIAM
DGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAAS
HSLYL
3D structure
PDB4qs7 Biochemical and structural study of Arabidopsis hexokinase 1
ChainA
Resolution2.001 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R108 S177 K192 D230
Catalytic site (residue number reindexed from 1) R75 S144 K159 D197
Enzyme Commision number 2.7.1.1: hexokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A S177 F178 T194 K195 N229 D230 N256 E284 E315 S144 F145 T161 K162 N196 D197 N223 E251 E282 MOAD: Kd=89uM
Gene Ontology
Molecular Function
GO:0001046 core promoter sequence-specific DNA binding
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005536 D-glucose binding
GO:0008270 zinc ion binding
GO:0008865 fructokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0009750 response to fructose
GO:0010148 transpiration
GO:0010182 sugar mediated signaling pathway
GO:0010255 glucose mediated signaling pathway
GO:0012501 programmed cell death
GO:0016310 phosphorylation
GO:0019318 hexose metabolic process
GO:0019320 hexose catabolic process
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
GO:0090332 stomatal closure
GO:2000032 regulation of secondary shoot formation
Cellular Component
GO:0000325 plant-type vacuole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0032991 protein-containing complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qs7, PDBe:4qs7, PDBj:4qs7
PDBsum4qs7
PubMed25664748
UniProtQ42525|HXK1_ARATH Hexokinase-1 (Gene Name=HXK1)

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