Structure of PDB 4qrc Chain A

Receptor sequence
>4qrcA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
LPLDPLWEFPRDRLVLGKPLGEGAFGQVVRAEAFGMDPARPDQASTVAVK
MLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA
AKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYL
ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPV
KWMAPEALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR
EGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV
3D structure
PDB4qrc DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
ChainA
Resolution1.901 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D612 A614 R616 N617 D630 R650
Catalytic site (residue number reindexed from 1) D159 A161 R163 N164 D177 R197
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI A L473 A501 K503 E520 M524 V550 C552 A553 L603 C608 I609 H610 R611 L619 A629 D630 F631 L633 L20 A48 K50 E67 M71 V97 C99 A100 L150 C155 I156 H157 R158 L166 A176 D177 F178 L180 PDBbind-CN: -logKd/Ki=6.34,IC50=452nM
BindingDB: IC50=8.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qrc, PDBe:4qrc, PDBj:4qrc
PDBsum4qrc
PubMed25317566
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

[Back to BioLiP]