Structure of PDB 4qqu Chain A

Receptor sequence
>4qquA (length=766) Species: 5476 (Candida albicans) [Search protein sequence]
MVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWKLQ
QKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMGRG
LQAAATTQAAVDVTALEMVKWFDSNYHYVRPTFSHSTEFKLNTAAGIKPV
DEFNEAKALGVQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYK
ELLQKLKEAGAEQVQIDEPVLVLDLPEAVQSKFKEAYDALVGADVPELIL
TTYFGDVRPNLKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGV
VDGRNIWKTDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETK
LDAVIKDWFSFATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSI
TNDPKVQERLTTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQ
TKDIRINRNKFAKGQITAEEYEAFINKEIETVVRFQEEIGLDVLVHGEPE
RNDMVQYFGEQLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKE
SVYAQSITSKPMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVN
DLEGAGITVIQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENS
TQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDPNYIQEFSEYPNHIGL
GLFDIHSPRIPSKQEFVSRIEEILKVYPASKFWVNPDCGLKTRGWPEVKE
SLTNMVEAAKEFRAKY
3D structure
PDB4qqu The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation.
ChainA
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H657 C659 C739 H656 C658 C738
BS02 39S A R16 K19 N126 Q451 K453 R456 R459 N503 D504 M505 W523 S526 R530 Y531 V532 W576 R16 K19 N125 Q450 K452 R455 R458 N502 D503 M504 W522 S525 R529 Y530 V531 W575
Gene Ontology
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006555 methionine metabolic process
GO:0006696 ergosterol biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0019280 L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine
GO:0032259 methylation
GO:0034605 cellular response to heat
GO:0052553 symbiont-mediated perturbation of host immune response
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0009277 fungal-type cell wall
GO:0009986 cell surface
GO:0030446 hyphal cell wall
GO:0062040 fungal biofilm matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4qqu, PDBe:4qqu, PDBj:4qqu
PDBsum4qqu
PubMed25545590
UniProtP82610|METE_CANAL 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Gene Name=MET6)

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