Structure of PDB 4qqc Chain A

Receptor sequence
>4qqcA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
DPLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDQA
STVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY
VIVECAAKGNLREFLRARRPPGPLSFPVLVSCAYQVARGMQYLESRKCIH
RDLAARNVLVTEDNVMKIADFGLLPVKWMAPEALFDEVYTHQSDVWSFGI
LLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWH
AAPSQRPTFKQLVEALDKVLLAV
3D structure
PDB4qqc Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 A614 R616 N617 D630
Catalytic site (residue number reindexed from 1) D152 A154 R156 N157 D170
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 37O A L473 E475 C477 F478 I534 V550 C552 A553 L619 D630 L31 E33 C35 F36 I87 V103 C105 A106 L159 D170 PDBbind-CN: -logKd/Ki=7.34,IC50=45.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4qqc, PDBe:4qqc, PDBj:4qqc
PDBsum4qqc
PubMed25349422
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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