Structure of PDB 4qps Chain A

Receptor sequence
>4qpsA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
PTIFEERHLKYISQLGKGNGSVELCRYDPLGDNTGALVAVKQLDQQRDFQ
REIQILKALHSDFIVKYRGVSYSLRLVMEYLPSGCLRDFLQRHRARLDAS
RLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEAHVKIADFGLAKLL
PLDKDYYVVPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSP
SAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAP
SPQDRPSFSALGPQLDMLWS
3D structure
PDB4qps Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) A125 A127 R129 N130 D143
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 37Q A L828 V836 A853 M902 Y904 L905 C909 R953 N954 L956 D967 L15 V22 A39 M78 Y80 L81 C85 R129 N130 L132 D143 PDBbind-CN: -logKd/Ki=6.52,IC50=0.30uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qps, PDBe:4qps, PDBj:4qps
PDBsum4qps
PubMed25552479
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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